He joined Sevilla in May 2017, having previously managed Estudiantes de La Plata (Argentina), O'Higgins (Chile) and RC Celta de Vigo, where he reached two Copa del Rey semi-finals and one UEFA Europa League semi-final. He managed the first team for the first half of 17/18, leaving the team fifth in La Liga and in the last 16 of the Copa del Rey and Champions League. He was sacked after the team's poor results in December.

The coach from Casilda (Argentina), who had led the Chilean national team to its first official title (Copa América 2015), arrived at the club in the summer of 2016 with the challenge of replacing the laureate Unai Emery. Under him, the team finished the league championship in fourth place, collecting a total of 72 points, and reached the last 16 of the Champions League. He left the club a year after his arrival to coach the Argentina national team.

The Argentine coach returned to the Sevilla bench several years later, in October 2022, replacing Julen Lopetegui as first-team coach. Despite qualifying for the quarter-finals of the UEFA Europa League, he was unable to lead Sevilla out of the bottom half of the league table, and was eventually replaced by José Luis Mendilibar in March 2023.

Unai Emery, from Guipuzcoa, was presented as a replacement for José Miguel González, Míchel, on 15 January 2013, remaining at the club until the end of the 2015/16 season.

In the summer of 2013, Emery was given the difficult challenge of returning Sevilla to the top of the table with a practically new team that had lost its main stars such as Jesús Navas, Álvaro Negredo, Kondogbia and Gary Medel, among others, during the summer. The Basque coach, after a difficult start, managed to successfully guide the revamped squad he was given and led the team to a fifth-place finish and the 2014 UEFA Europa League championship. In the two subsequent seasons, despite multiple changes to the squad, he kept Sevilla on top and won two more UEFA Europa League titles - 2015 and 2016 - as well as playing in three European Super Cup finals and a Copa del Rey final against FC Barcelona in May 2016, which they lost in extra time.

Under him, in 14/15 Sevilla FC achieved their best-ever league points tally at the time (76 points), which, however, was only good enough to finish fifth. With 106 victories to his name, Unai Emery is the coach with the most wins in domestic and international competition.

Following the sacking of Marcelino García Toral in the middle of the 2011/12 season, Sevilla FC appointed Míchel as the Asturian's replacement at the helm of the club's first team. The Madrid-born coach remained in charge until midway through the following season, when after a poor first half of the season, which left the team in twelfth position with just 22 points, he was sacked and replaced by Unai Emery.

The Asturian coach took charge of the Sevilla FC first team at the start of the 2011/12 season. After a run of more than two months without a win, taking just five points from 21 in La Liga, Marcelino was sacked on 6 February 2012, having previously lost in the last 16 of the Copa del Rey and in the UEFA Europa League qualifying round.

He joined Sevilla to replace Antonio Álvarez at the end of September 2010. For the rest of the 2010/11 season in charge of the first team, Goyo Manzano managed to finish fifth in the league championship, losing in the Copa del Rey and UEFA Europa League to Real Madrid and Porto, clubs that would go on to become champions of those competitions.

Following the departure of José Antonio Camacho, Antonio Álvarez was appointed to take charge of the Sevilla squad, on an interim basis, until the arrival of Carlos Salvador Bilardo. During this first period, Álvarez was in charge of the team for just one matchday, the 23rd of the 1996/1997 season, when they lost to Real Zaragoza by two goals to one at La Romareda.

After this short-lived first spell, Álvarez returned to the Sevilla bench at the end of the 2009/10 season, replacing Manolo Jiménez. Thus, the club's sporting management showed their confidence in a local man, who had previously acquired enormous experience as assistant coach to Joaquín Caparrós and Juande Ramos, among others. During the ten league games that remained to be played, Álvarez managed to lift the team from fifth to fourth place, thus qualifying them for the qualifying round of the next edition of the Champions League. The icing on the cake was the Copa del Rey, for which the club had already reached the final under Jiménez.

The successes achieved at the end of the 09/10 season earned the coach his continuity at the helm of the team for the following season. However, defeat against FC Barcelona in the final of the Spanish Super Cup, together with elimination at the hands of Sporting Braga in the Champions League qualifiers and a shaky start to the league campaign, led to the dismissal of the coach at the end of September 2010, and he was replaced by Gregorio Manzano.

Former Sevilla international Manolo Jiménez took over as first team coach after Juande Ramos' departure in October 2007 from Sevilla Atlético, the club he was managing at the time. During his first season, he managed to straighten out a team that was languishing in mid-table, leaving them in fifth place. In the following season, 2008/09, despite the departure of important players and an early elimination from European competition, Jiménez managed to get the team to third place, reaching the semi-finals of the Spanish Cup.

Jiménez would hold the position of Sevilla coach until March 2010, when, after a series of matches without a win, he was dismissed from his post. By then, however, he had managed to qualify the team for the final of the Spanish Cup, which would eventually be won by the Nervión club under his replacement Antonio Álvarez.

The La Mancha-born coach joined the Nervión outfit at the start of the 2005/06 season to replace Caparrós, and remained in charge of the first team until the end of October 2007, when he decided to leave the club by terminating his contract with mutual consent.

During his successful tenure, Sevilla FC won the UEFA Cup twice (2006 and 2007), won the European Super Cup (2006), won the Spanish Cup and Super Cup (2007) and was named Best Club in the World by the IFFHS in 2006 and 2007. Under his guidance, Sevilla FC fought for the league title in 06/07 until the last matchday. He is the most successful coach in the history of Sevilla FC.

The Utrera-born coach arrived at Sevilla under the guidance of the then president Roberto Alés and his sporting director, Ramón Rodríguez Verdejo, Monchi, at the beginning of the 2000/01 season, with the sole objective of attempting the all-out challenge to reach the First Division. During his first season in charge of the first team, Caparrós achieved the long-awaited promotion, winning the Second Division title by a landslide.

Over the next four seasons in the Sevilla dugout, the Utrera native not only managed to secure Sevilla's place in the top flight, but also to qualify for the UEFA Cup on two occasions. It was the second of these, achieved at the end of his last season at the club, that would lead to the club's first European silverware a year later.

Almost 13 years after his departure, Caparrós returned to the club in April 2018 following the sacking of Vincenzo Montella. With just three games left in the season plus the postponed match against Real Madrid, the Utrerano's mission was to qualify the team for the UEFA Europa League. He even did so with a game to spare, managing three wins and a draw. At the end of the season, it was announced that he would move into the office as the club's director of football.

In March 2019, he began his third spell in charge of the Sevilla bench following the dismissal of Pablo Machín, leaving his post as the club's Director of Football. With a balance of six wins, one draw and four defeats in the last eleven league games, he tied for sixth place, which allowed Sevilla FC to qualify directly for the group stage of the UEFA Europa League.