Rayo Vallecano-Sevilla FC, in the 22nd matchday of LaLiga, which will be played at the Estadio de Vallecas at 16:15 on Sunday.
Nine points separate the two teams in the table. The home side, in European places, are in sixth place on 33 points, while Sampaoli's men are in twelfth place on 24 points.
Iraola has Fran Garcia at left-back, Isi Palazón in attacking midfield and Sergio Camello up front as the mainstays of his squad, among others.
Two draws and a win are Sevilla's last results at Vallecas. Last season, with a 1-1 draw, and in 15/16, with a 2-2 draw, while in 18/19, on the opening day of the season, Pablo Machín's side thrashed the Madrid side 4-1.
Jorge Sampaoli has sent 21 players to the Spanish capital, with Badé, Gudelj and Jordán the most notable absentees.
The match will be officiated by referee Jesús Gil Manzano, assisted by Santiago Jaime Latre on VAR.